At the beginning of the 17th century, Spanish Jesuits, began building settlements over a vast area of ​​the Paraná region in southeastern South America, now the border zone between Argentina, Paraguay, and Brazil. These settlements, known as reductions (or "communities" in the terminology of the time), allowed the Guarani people to live in peace without being enslaved, preserving their language, culture, and social structure in exchange for accepting evangelization. They became known as reductions or the "Republic of the Indians."

The missions were a subject of discussion in the power circles of major European courts. Voltaire, despite being a fierce critic of religion, regarded the Jesuit experience as a "triumph of humanity."

The Path of the Missions is a journey of discovery through the vast cultural, spiritual, and organizational legacy of the Jesuits and the Guaraní people. It is an adventure through the unknown and the untamed, an opportunity to engage with native communities that have preserved their traditions for centuries. It offers the chance to marvel at the advanced architecture of their missions—many of which have been declared UNESCO World Heritage Sites—forming an unparalleled legacy still present in Argentina, Paraguay, and Brazil.